D-Mannose
D-Mannose bulk ingredient for B2B formulation sourcing. Request a specification sheet, batch COA, and documentation from GEM.
| 规格名称 | 规格值 |
|---|---|
| Assay | 98.0%–102% |
| Forms | Powder; Granule; Tablets |
| CAS No. | 3458-28-4 |
| Origin | Corn (maize) derived |
| Shelf Life | 36 months |
| Stock | EU & USA warehouse storage |
D-Mannose
D-Mannose is a naturally occurring six-carbon monosaccharide (CAS 3458-28-4) used in dietary supplements and functional foods. GEM supplies corn-derived D-Mannose at 98.0%–102% assay (HPLC) in powder, granule, and tablet forms for global B2B customers.
D-Mannose Quick View
Specification: 98.0%–102% HPLC
Available Forms: Powder · Granule · Tablets
Powder Mesh: 20 mesh; 30 mesh; 40 mesh; 80 mesh
Granule Mesh: 20 mesh (customizable)
Tablets: 500 mg/tablet; 1 g/tablet (customizable)
CAS No.: 3458-28-4
Molecular Formula: C6H12O6 · Molecular Weight: 180.16
Certificate: ISO22000; ISO14001; ISO9001; FSSC22000; GMP; Kosher; Halal
Annual Production Capacity: 500+ tons
Shelf Life: 36 months
Application: Dietary supplements; Women's health formulas; Functional foods and beverages; Pharmaceutical excipients; Nutritional ingredients; Cosmetics
Packing: 25 kg/drum, 2 layers PE bags inside
Last updated: June 21, 2026
What Is D-Mannose?
D-Mannose is a naturally occurring six-carbon monosaccharide (aldohexose) that appears as white crystals or crystalline powder. It is an epimer of glucose and participates in protein glycosylation within human metabolism.
GEM D-Mannose is produced from glucose derived from corn (maize) through controlled isomerization, chromatographic separation, and multi-stage crystallization. The result is a high-purity ingredient at 98%–102% assay (HPLC), suitable for global supplement and functional food markets.
Available Forms — Choose the Right Format for Your Line
GEM supplies D-Mannose in three commercial formats to match different manufacturing workflows:
D-Mannose Powder
Suitable for sachets, stick packs, bulk powder blends, and drink mixes. 30 mesh is a commonly requested grade; confirm its flowability and dissolution performance through your own manufacturing trial.
Available mesh: 20 · 30 · 40 · 80 mesh (custom mesh upon request)
D-Mannose Granule
Engineered for capsule filling and direct compression tableting. Granules offer superior flow properties compared to fine powder, reducing capping and weight variation on high-speed encapsulation lines. Also recommended as an intermediate for in-house tablet production.
Available mesh: 20 mesh (customized upon request)
D-Mannose Tablets
Ready-to-market finished dosage form for brands seeking turnkey supply. Oval shape for easy swallowing; custom shapes, sizes, and embossed logos available.
Available sizes: 500 mg/tablet · 1 g/tablet (customized upon request)
Quality Specification
| Testing Item | Specification | Test Method |
|---|---|---|
| Appearance | White crystals or crystalline powder | Visual |
| Clarity (solution) | Clear and colorless | Visual |
| Assay | 98.0%–102% | HPLC |
| Melting Point | 126 – 134 °C | USP-NF<741> |
| Specific Rotation | +13.3° – +14.3° | USP-NF<781> |
| Loss on Drying | ≤ 1.0 % | USP-NF<731> |
| Residue on Ignition | ≤ 0.1% | USP-NF<281> |
| Bulk Density (g/ml) | 0.35 – 0.55 | USP-NF<616> |
| Tapped Density (g/ml) | 0.50 – 0.80 | USP-NF<616> |
| Total Heavy Metals | ≤ 10 mg/kg | USP-NF<231> |
| Arsenic (As) | ≤ 1.0 mg/kg | ICP-MS |
| Cadmium (Cd) | ≤ 0.5 mg/kg | ICP-MS |
| Lead (Pb) | ≤ 1.0 mg/kg | ICP-MS |
| Mercury (Hg) | ≤ 0.1 mg/kg | ICP-MS |
| Total Plate Count | ≤ 500 cfu/g | USP-NF<2021> |
| Molds and Yeasts | ≤ 100 cfu/g | USP-NF<2021> |
| Salmonella | Absence/25g | USP-NF<2022> |
| E. Coli | Absence/10g | USP-NF<2022> |
| Staphylococcus aureus | Absence/10g | USP-NF<2022> |
Remark: Bulk density and tapped density can be adjusted to meet your encapsulation or tableting requirements. Contact GEM to request Specification Sheet, COA, and MSDS for any form.
Production Process
Glucose → Isomerization → Decoloration → Desalination → Chromatographic Separation → Mannose Fraction → Concentration → Crystallization → Dissolution & Decoloration → Re-concentration → Re-crystallization → Drying → Sieving → Packing → Finished Product
GEM operates integrated production with 500+ tons annual capacity, supported by EU and USA warehouse storage for faster delivery to international B2B customers.
Frequently Asked Questions
1. What is the source of GEM D-Mannose?
All GEM D-Mannose is produced from glucose derived from corn (maize) via isomerization and chromatographic purification. We do not currently supply birch-sourced D-Mannose.
2. Which mesh size should I choose for capsule filling?
For encapsulation, we recommend D-Mannose Granule (20 mesh) for optimal flow on automatic capsule fillers. If using powder, 30 mesh is our most popular grade for general supplement manufacturing.
3. Can bulk density be customized?
Yes. Bulk density (0.35–0.55 g/ml) and tapped density (0.50–0.80 g/ml) can be adjusted to match your encapsulation or tableting equipment. Share your target parameters when requesting a quote.
4. What is a typical daily serving in finished products?
Finished-product serving size must be established by the brand and reviewed for the target market. GEM can provide ingredient documentation and formulation information but does not offer medical advice.
6. Why does D-Mannose taste slightly bitter?
The mild bitterness comes from the beta-anomer of D-Mannose, while the alpha-anomer contributes sweetness. This is a natural characteristic of the material and does not indicate quality issues.
7. What quality documents do you provide for B2B orders?
We provide Specification Sheet, COA (Certificate of Analysis), and MSDS upon request. Kosher, Halal, and ISO/FSSC certificates are available for qualified commercial orders.
9. Do you offer EU and USA warehouse delivery?
Yes. GEM maintains EU and USA warehouse storage for select SKUs, enabling faster fulfillment for international B2B customers. Confirm availability for your specific form and mesh grade at order time.